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| First Name: | Troy | | Last Name: | Rohn | | Title: | Assistant Professor | | Advanced Degrees: | Ph.D. | | Affiliation: | Boise State University | | Department: | Biology | | Street Address 1: | 1910 University Avenue | | Street Address 2: | Science/Nursing Building #228 | | City: | Boise | | State/Province: | ID | | Zip/Postal Code: | 83725 | Country/Territory: | U.S.A. | | Phone: | 208-426-2396 | | Fax: | 208-426-4267 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 16 April 2004]
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View all comments by Troy Rohn
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Tauopathies, Alzheimer Disease
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Molecular and Cell biology, A-beta PP/A-beta, Apoptosis/Cell cycle, Tau/Cytoskeleton
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Troy Rohn graduated in 1990 from the University of California at Davis with a B.S. in Physiology. He received his Ph.D. in Pharmacology from the University of Washington, Seattle in 1994. His interests include the role of apoptosis in neurodegenerative diseases. Dr. Rohn had several Postdoctoral stints including two plus years living in Paris, France, one year at Montana State University in Bozeman, Montana, and two years at UC Irvine in the Department of Brain Aging and Dementia. |
Rohn, T.T., Cusack, S.M., Kessinger, S.R., and Oxford, J.T. (2004). Caspase activation independent of cell death is required for proper cell dispersal and correct morphology in PC12 cells. Experimental Cell Research (In Press).
Rissman, R.A., Poon, W.W., Blurton-Jones, M., Oddo, S., Torp, R., LaFerla, F.M., Rohn, T.T. and Cotman, C.W. (2004). Caspase-dependent cleavage of tau is an early event in Alzheimer’s disease tangle pathology. Journal of Clinical Investigation (In Press).
Chung, C-W, Hong, Y-M, Song, Woo, H-N, Choi, Y-H, Rohn, T.T. and Jung, Y-K. (2003). Atypical role of proximal caspase-8 in truncated tau-induced neurite regression and neuronal cell death. Neurobiol Dis 14(3): 557-566.
Rohn, T.T., Rissman, R.A., Head, E. and Cotman, C.W. (2002). Caspase activiation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News & Perspectives 15(9): 549-557.
Rohn, T.T., Rissman, R.A., Davis, M.C., Kim, Y., Cotman, C.W. and Head, E. (2002). Caspase-9 activation and caspase cleavage of tau in the Alzheimer’s disease brain. Neurobiol Dis 11:341-354.
Head, E., Lott, I.T., Cribbs, D.H., Cotman, C.W. and Rohn, T.T. (2002). b-Amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci. Lett 330: 99-103.
Rohn, T.T., Head, E., Su, J.H., Anderson, A.J., Bahr, B.A., Cotman, C.W. and Cribbs, D.H. (2001) Evidence for caspase activation in tangle-bearing neurons in Alzheimer’s disease. American Journal of Pathology 158: 189-198 (See Commentary, page 1-2)
Rohn, T.T., Wong, S.M., Cotman, C.W. and Cribbs, D.H. (2001). 15-Deoxy-D12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor, induces neuronal apoptosis. NeuroReport 12: 839-843.
Rohn, T.T., Head, E., Nesse, W.P., Cotman, C.W. and Cribbs, D.H. (2001). Activation of caspase-8 in the Alzheimer’s disease brain. Neurobiology of Disease 8:1006-1016.
Rohn, T.T., Ivins, K.J., Bahr, B.A., Cotman, C.W. and Cribbs, D.H. (2000) A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J. Neurochem. 74: 2331-2342. |
What is the link between beta-amyloid and tangles. |
That caspase activation leads to cleavage of tau and this promotes neurofibrillary tangle formation |
Using transgenic mice that produce plaques and tangles and pharmacologically blocking caspase activation to see if it attenuates tangle formation |
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